GPR119 May Join CB1 and CB2 As a Cannabinoid Receptor

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GPR119 is a receptor embedded in the cell membranes of certain cells in all mammals that have been tested so far, including humans. It functions by receiving signals from very specific molecules that are able to “lock” onto it and activate it. Like other cannabinoid receptors, or potential cannabinoid receptors, the GPR119 receptor can receive […]

The GPR55 Receptor and How CBD Interacts With It

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GPR55 is a “G protein receptor” that is embedded within the cell membrane. This is where the “GPR” part of the name comes from. G protein receptors are a very broad family of cell membrane receptors that all have a similar sinuous structure, crossing through the cell membrane seven times. All G protein receptors receive […]

GPR55: The Leading Candidate For the CB3 Cannabinoid Receptor

GPR55 is a cell membrane receptor that was first identified in the brain in 1999. It was also cloned that year. By looking at the gene sequence, its physical structure, and the specific molecules that interacted with it, scientists began to speculate that it might be a cannabinoid receptor like CB1 and CB2. The majority […]

How Terpenes Work Synergistically With Cannabinoids

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Terpenes are abundant in cannabis and cannabis oils (CBD oil). There have been more than two hundred terpenes found in the cannabis plant but only the ones in concentrations of 0.05 percent or higher are of interest from a therapeutic perspective, working in conjunction with cannabinoids. Almost all of the interesting aromas associated with different […]

Terpenes in Cannabis: Sabinene

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Sabinene is considered a secondary terpene in the cannabis plant because the concentrations of this terpene are quite low. However, even at low concentrations, sabinene can alter the aromatic qualities of different strains of cannabis due to its powerful spicy punch. It is one of two terpenes, along with caryophyllene (beta caryophyllene), that give black […]

Terpenes in Cannabis: Terpineol

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One of the most sought after terpenes in cannabis oil is terpineol. There are at least four naturally occurring isomers of terpineol in cannabis. These are alpha terpineol, (α-terpineol), beta terpineol (β-terpineol), gamma terpineol (γ-terpineol), and 4-terpineol (also sometimes called terpinen-4-ol). Alpha terpineol is the most common and best studied of the four isomers. Terpineol […]